Publications by authors named "Michelle Tellez-Sutterlin"
Unlabelled: The With No lysine (WNK) kinases regulate processes such as cell volume and epithelial ion transport through the modulation of Cation Chloride Cotransporters such as the NaCl cotransporter, NCC, present in the distal convoluted tubule (DCT) of the kidney. Recently, the interaction of WNKs with Nuclear Receptor Binding Protein 1 (NRBP1) and Transforming Growth Factor β-Stimulated Clone 22 Domain (TSC22D) proteins was reported. Here we explored the effect of NRBP1 and TSC22Ds on WNK signaling in vitro and in the DCT.
View Article and Find Full Text PDFArginine vasopressin regulates the renal Na-Cl and Na-K-Cl cotransporters through with-no-lysine kinase 4 and inhibitor 1 phosphorylation.
Hector Carbajal-Contreras Adrian Rafael Murillo-de-Ozores German Magaña-Avila Alejandro Marquez-Salinas Laurent Bourqui Michelle Tellez-Sutterlin
Am J Physiol Renal Physiol
February 2024
Article Synopsis
- Vasopressin helps the body manage water levels by working with a special receptor in the kidneys which uses protein kinase A (PKA).
- It increases the activity of two transporters, NCC and NKCC2, which help move salt and water in the kidneys, through pathways involving other proteins like WNK and SPAK.
- In experiments, scientists found that a specific protein called WNK4 is very important for how these signals work together when vasopressin is present.