Publications by authors named "Michelle Rossberg"
Background: The timing of coronary angiography in patients with successfully resuscitated out-of-hospital cardiac arrest and missing ST-segment elevations on the electrocardiogram has been investigated in 2 large randomized controlled trials, TOMAHAWK (Angiography After Out-of-Hospital Cardiac Arrest Without ST-Segment Elevation) and COACT (Coronary Angiography After Cardiac Arrest Trial). Both trials found neutral results for immediate vs delayed/selective coronary angiography on short-term all-cause mortality. The TOMAHAWK trial showed a tendency towards harm with immediate coronary angiography, though not statistically significant with traditional frequentist methods.
View Article and Find Full Text PDFPurpose Of Review: Treatment of cardiogenic shock remains largely driven by expert consensus due to limited evidence from randomized controlled trials. In this review, we aim to summarize the approach to the management of patients with cardiogenic shock in the ICU prior to mechanical circulatory support (MCS).
Recent Findings: Main topics covered in this article include diagnosis, monitoring, initial management and key aspects of pharmacological therapy in the ICU for patients with cardiogenic shock.
Background: In Europe, more than 300,000 persons per year experience out-of-hospital cardiac arrest (OHCA). Despite medical progress, only few patients survive with good neurological outcome. For many issues, evidence from randomized trials is scarce.
View Article and Find Full Text PDFArticle Synopsis
- - Pulmonary Hypertension (PH) is a serious disorder involving changes in blood vessels and heart muscle, with specific fetal variants of fibronectin (ED-A and ED-B Fn) being potential biomarkers and therapeutic targets for diagnosing and treating the condition.
- - A study measured serum levels of ED-A and ED-B Fn in 80 PH patients and 40 healthy controls, finding significantly higher levels of ED-A Fn in PH patients compared to controls, while ED-B Fn levels did not show significant differences.
- - Further analysis indicated that increased ED-A Fn levels correlated with other clinical indicators, such as brain natriuretic peptide levels and pulmonary artery pressure, suggesting its potential utility in understanding and managing PH.