How schema knowledge influences memory in older adults: Filling in the gaps, or leading memory astray?

Age-related declines in episodic memory do not affect all types of mnemonic information equally: when to-be-remembered information is in line with one's prior knowledge, or schema-congruent, older adults often show no impairments. There are two major accounts of this effect: One proposes that schemas compensate for memory failures in aging, and the other proposes that schemas instead actively impair older adults' otherwise intact memory for incongruent information. However, the evidence thus far is inconclusive, likely due to methodological constraints in teasing apart these complex underlying dynamics.

Divergent thinking modulates interactions between episodic memory and schema knowledge: Controlled and spontaneous episodic retrieval processes.

The ability to generate novel ideas, known as divergent thinking, depends on both semantic knowledge and episodic memory. Semantic knowledge and episodic memory are known to interact to support memory decisions, but how they may interact to support divergent thinking is unknown. Moreover, it is debated whether divergent thinking relies on spontaneous or controlled retrieval processes.

Lung microenvironments harbor phenotypes with distinct treatment responses.

Tuberculosis lung lesions are complex and harbor heterogeneous microenvironments that influence antibiotic effectiveness. Major strides have been made recently in understanding drug pharmacokinetics in pulmonary lesions, but the bacterial phenotypes that arise under these conditions and their contribution to drug tolerance are poorly understood. A pharmacodynamic marker called the RS ratio quantifies ongoing rRNA synthesis based on the abundance of newly synthesized precursor rRNA relative to mature structural rRNA.

Eye movements dissociate between perceiving, sensing, and unconscious change detection in scenes.

Detecting visual changes can be based on perceiving, whereby one can identify a specific detail that has changed, on sensing, whereby one knows that there is a change but is unable to identify what changed, or on unconscious change detection, whereby one is unaware of any change even though the change influences one's behavior. Prior work has indicated that the processes underlying these different types of change detection are functionally and neurally distinct, but the attentional mechanisms that are related to these different types of change detection remain largely unknown. In the current experiment, we examined eye movements during a change detection task in globally manipulated scenes, and participants indicated their change detection confidence on a scale that allowed us to isolate perceiving, sensing, and unconscious change detection.

Episodic memory processes modulate how schema knowledge is used in spatial memory decisions.

Schema knowledge can dramatically affect how we encode and retrieve memories. Current models propose that schema information is combined with episodic memory at retrieval to influence memory decisions, but it is not known how the strength or type of episodic memory (i.e.

Combination of Mycobacterium tuberculosis RS Ratio and CFU Improves the Ability of Murine Efficacy Experiments to Distinguish between Drug Treatments.

Murine tuberculosis drug efficacy studies have historically monitored bacterial burden based on CFU of Mycobacterium tuberculosis in lung homogenate. In an alternative approach, a recently described molecular pharmacodynamic marker called the RS ratio quantifies drug effect on a fundamental cellular process, ongoing rRNA synthesis. Here, we evaluated the ability of different pharmacodynamic markers to distinguish between treatments in three BALB/c mouse experiments at two institutions.

Model-Based Meta-Analysis of Relapsing Mouse Model Studies from the Critical Path to Tuberculosis Drug Regimens Initiative Database.

Tuberculosis (TB), the disease caused by Mycobacterium tuberculosis (Mtb), remains a leading infectious disease-related cause of death worldwide, necessitating the development of new and improved treatment regimens. Nonclinical evaluation of candidate drug combinations via the relapsing mouse model (RMM) is an important step in regimen development, through which candidate regimens that provide the greatest decrease in the probability of relapse following treatment in mice may be identified for further development. Although RMM studies are a critical tool to evaluate regimen efficacy, making comprehensive "apples to apples" comparisons of regimen performance in the RMM has been a challenge in large part due to the need to evaluate and adjust for variability across studies arising from differences in design and execution.

Comparative Analysis of Pharmacodynamics in the C3HeB/FeJ Mouse Tuberculosis Model for DprE1 Inhibitors TBA-7371, PBTZ169, and OPC-167832.

Multiple drug discovery initiatives for tuberculosis are currently ongoing to identify and develop new potent drugs with novel targets in order to shorten treatment duration. One of the drug classes with a new mode of action is DprE1 inhibitors targeting an essential process in cell wall synthesis of Mycobacterium tuberculosis. In this investigation, three DprE1 inhibitors currently in clinical trials, TBA-7371, PBTZ169, and OPC-167832, were evaluated side-by-side as single agents in the C3HeB/FeJ mouse model presenting with caseous necrotic pulmonary lesions upon tuberculosis infection.

Mycobacterium tuberculosis precursor rRNA as a measure of treatment-shortening activity of drugs and regimens.

There is urgent need for new drug regimens that more rapidly cure tuberculosis (TB). Existing TB drugs and regimens vary in treatment-shortening activity, but the molecular basis of these differences is unclear, and no existing assay directly quantifies the ability of a drug or regimen to shorten treatment. Here, we show that drugs historically classified as sterilizing and non-sterilizing have distinct impacts on a fundamental aspect of Mycobacterium tuberculosis physiology: ribosomal RNA (rRNA) synthesis.

Why do we retrace our visual steps? Semantic and episodic memory in gaze reinstatement.

When we look at repeated scenes, we tend to visit similar regions each time-a phenomenon known as Resampling has long been attributed to episodic memory, but the relationship between resampling and episodic memory has recently been found to be less consistent than assumed. A possibility that has yet to be fully considered is that factors unrelated to episodic memory may generate resampling: for example, other factors such as semantic memory and visual salience that are consistently present each time an image is viewed and are independent of specific prior viewing instances. We addressed this possibility by tracking participants' eyes during scene viewing to examine how semantic memory, indexed by the semantic informativeness of scene regions (i.

Markers of a plant-based diet relate to memory and executive function in older adults.

Background: Although it is known that plant-based foods are important for physical health, little is known about the relationship between plant-based foods and cognitive health. Emerging evidence suggests that some macronutrients may influence cognition, but it is unclear which domains of cognition are involved; more importantly, it is unknown how a plant-based diet relates to cognition.

Objective: To examine associations between a plant-based dietary pattern and cognitive functioning.

Digital Image Analysis of Heterogeneous Tuberculosis Pulmonary Pathology in Non-Clinical Animal Models using Deep Convolutional Neural Networks.

Efforts to develop effective and safe drugs for treatment of tuberculosis require preclinical evaluation in animal models. Alongside efficacy testing of novel therapies, effects on pulmonary pathology and disease progression are monitored by using histopathology images from these infected animals. To compare the severity of disease across treatment cohorts, pathologists have historically assigned a semi-quantitative histopathology score that may be subjective in terms of their training, experience, and personal bias.

The spatial distribution of attention predicts familiarity strength during encoding and retrieval.

The memories we form are determined by what we attend to, and conversely, what we attend to is influenced by our memory for past experiences. Although we know that shifts of attention via eye movements are related to memory during encoding and retrieval, the role of specific memory processes in this relationship is unclear. There is evidence that attention may be especially important for some forms of memory (i.

Mild acute stress improves response speed without impairing accuracy or interference control in two selective attention tasks: Implications for theories of stress and cognition.

Acute stress is generally thought to impair performance on tasks thought to rely on selective attention. This effect has been well established for moderate to severe stressors, but no study has examined how a mild stressor-the most common type of stressor-influences selective attention. In addition, no study to date has examined how stress influences the component processes involved in overall selective attention task performance, such as controlled attention, automatic attentional activation, decision-making, and motor abilities.

Determining the mechanisms through which recent life stress predicts working memory impairments: precision or capacity?

Prior research has found that recent life stress exposure is related to poorer working memory performance, but it remains unclear which aspects of working memory are related to stress. To address this important issue, we examined the extent to which recent life stress exposure was associated with working memory capacity (i.e.

Conscious and unconscious memory differentially impact attention: Eye movements, visual search, and recognition processes.

A hotly debated question is whether memory influences attention through conscious or unconscious processes. To address this controversy, we measured eye movements while participants searched repeated real-world scenes for embedded targets, and we assessed memory for each scene using confidence-based methods to isolate different states of subjective memory awareness. We found that memory-informed eye movements during visual search were predicted both by conscious recollection, which led to a highly precise first eye movement toward the remembered location, and by unconscious memory, which increased search efficiency by gradually directing the eyes toward the target throughout the search trial.

Effectiveness of wraparound versus case management for children and adolescents: results of a randomized study.

In this study, we compared service experiences and outcomes for youths with serious emotional disorder (SED) randomly assigned to care coordination via a defined wraparound process (n = 47) versus more traditional intensive case management (ICM; n = 46) The wraparound group received more mean hours of care management and services; however, there ultimately were no group differences in restrictiveness of residential placement, emotional and behavioral symptoms, or functioning. Wraparound implementation fidelity was found to be poor. Organizational culture and climate, and worker morale, were poorer for the wraparound providers than the ICM group.