Publications by authors named "Michelle Queau"
Article Synopsis
- Student retention in nursing programs is a critical issue impacting the supply of nurses in healthcare, necessitating effective strategies that consider both social and academic integration.
- This systematic review, utilizing Joanna Briggs Institute methods, analyzes retention strategies implemented in nursing programs globally, drawing data from 112 studies published between 1998 and 2019.
- The most common retention strategies involve mentorship, study skills development, and tutoring, with the most successful being comprehensive programs that offer diversified pathways based on students' academic assessments.
Lenalidomide has anti-tumor activity in CLL but can be complicated by tumor lysis syndrome (TLS) and tumor flare (TF). In our previous study using low-dose lenalidomide in treatment-naive CLL, TLS was averted but TF remained frequent and complete responses (CR) were rare, despite treatment to progression. The addition of dexamethasone may mitigate TF and enable lenalidomide dose escalation, achieving durable response without long-term use.
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- * The treatment was generally well tolerated, though respiratory infections occurred frequently, with almost 20% requiring hospitalization, and some patients experienced manageable blood-related side effects.
- * Results showed a 50% overall response rate but limited durable outcomes, with a median progression-free survival of 8.5 months and an overall survival of 34.8 months, suggesting that this combination may not be more beneficial than using ofatumumab alone
Bendamustine (BEN) has structural similarities to an alkylating agent and a nucleoside analog, and effective against tumor cells that are resistant to standard therapy. In this study we compared the activities of BEN against that of the alkylating agent, chlorambucil (CLB), and the nucleoside analogs, fludarabine (FLU) and deoxyadenosine/pentostatin (dADO/PEN), in primary chronic lymphocytic leukemia (CLL) cells in vitro. Cross-resistance was observed between BEN, CLB and FLU, with previously treated patients or those with a deletion 17p being most resistant.
View Article and Find Full Text PDFMcl-1 is an anti-apoptotic Bcl-2 family member that is often over-expressed in the malignant brain tumor glioblastoma (GBM). It has been previously shown that epidermal growth factor receptors up-regulate Mcl-1 contributing to a cell survival response. Hypoxia is a poor prognostic marker in glioblastoma despite the fact that hypoxic regions have areas of necrosis.
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