Publications by authors named "Michelle Pilligua-Lucas"
Article Synopsis
- Polyphenylene carboxymethylene (PPCM) is a condensation polymer showing potential as a contraceptive and antimicrobial agent against various viruses, including HIV and gonorrhea, with a strong safety profile.
- The study evaluated PPCM's effectiveness using both in vitro tests and a mouse model, finding that a vaginal gel formulation (Yaso-GEL) containing PPCM successfully prevented gonorrhea infection in 100% of tested mice.
- The results suggest Yaso-GEL could be a cost-effective, non-hormonal solution for preventing both unintended pregnancies and sexually transmitted infections (STIs), highlighting the need for such products for women across different demographics.
Murine models of Neisseria gonorrhoeae lower reproductive tract infection are valuable systems for studying N. gonorrhoeae adaptation to the female host and immune responses to infection. These models have also accelerated preclinical testing of candidate therapeutic and prophylactic products against gonorrhea.
View Article and Find Full Text PDFThe mucosa is colonized with commensal Neisseria. Some of these niches are sites of infection for the STD pathogen Neisseria gonorrhoeae (Ngo). Given the antagonistic behavior of commensal bacteria toward their pathogenic relatives, we hypothesized that commensal Neisseria may negatively affect Ngo colonization.
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