A cross-generational methylomic signature of infant maltreatment in newborn rhesus macaques.

Background: Early life adversity (ELA) result in detrimental physical and mental health outcomes. The impact of ELA can reverberate across generations, with epigenetic modifications being one of the proposed biological correlates of exposure to ELA. Here we bridge the translational gap between rodent models and clinical studies by utilizing a nonhuman primate model to study the cross-generational epigenetic and functional footprints of physical maltreatment and neglect.