Publications by authors named "Michelle Min Fang Yee"
The management of bone defects is complicated by the presence of clinical conditions, such as critical-sized defects created by high-energy trauma, tumour resection, infection, and skeletal abnormalities, whereby the bone regeneration capacity is compromised. A bone scaffold is a three-dimensional structure matrix serving as a template to be implanted into the defects to promote vascularisation, growth factor recruitment, osteogenesis, osteoconduction, and mechanical support. This review aims to summarise the types and applications of natural and synthetic scaffolds currently adopted in bone tissue engineering.
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- Vitamin A, crucial for growth, immunity, and vision, exists in two forms: retinol from animal sources and provitamin A from plants, affecting bone health differently.
- High levels of retinol can negatively impact bone density, especially in individuals with obesity or vitamin D deficiency, while adequate intake supports bone health.
- Both provitamin A compounds, like carotene and β-cryptoxanthin, may enhance bone protection by promoting bone formation and inhibiting harmful bone cell activity, suggesting further research is needed to confirm their benefits.