Publications by authors named "Michelle McCorkell"
Article Synopsis
- There is a need for better animal models to study meibomian gland dysfunction (MGD) and evaporative dry eye disease (EDED), leading researchers to evaluate Awat2 knockout (KO) mice for this purpose.
- The study involved various tests on both wildtype and Awat2 KO mice, including ocular examinations, lipid analysis, and gene expression assessments.
- Results showed that Awat2 KO mice exhibited characteristics similar to human MGD and EDED, such as corneal issues and impaired meibum secretion, making them suitable for testing new treatments.
Although biomechanical changes of the trabecular meshwork (TM) are important to the pathogenesis of glucocorticoids-induced ocular hypertension (GC-OHT), there is a knowledge gap in the underlying molecular mechanisms of the development of it. In this study, we performed intravitreal triamcinolone injection (IVTA) in one eye of 3 rhesus macaques. Following IVTA, we assessed TM stiffness using atomic force microscopy and investigated changes in proteomic and miRNA expression profiles.
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