Heteroresistance to cefiderocol in carbapenem-resistant in the CREDIBLE-CR study was not linked to clinical outcomes: a analysis.

The population analysis profiling (PAP) test is considered the "gold standard" method to detect heteroresistance. It exposes bacteria to increasing concentrations of antibiotics at high cell densities to detect any minority resistant subpopulations that might be missed by the low inoculums used for reference susceptibility tests. However, its clinical relevance has not been well established.