Publications by authors named "Michelle Maloney"
We evaluated pediatric obesity clinics for internal referrals developed at 5 primary care offices. Clinics developed site-specific strategies: 1 group approach and 4 clinics providing individualized care only. Clinicians reported patient/family motivation as an important referral consideration and compliance as the greatest challenge and perceive clinics to have provided some help.
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- Age-related macular degeneration (AMD) is a major cause of blindness, affecting the retina and leading to irreversible vision loss, but its underlying molecular mechanisms are not fully understood.
- Researchers conducted a transcriptome analysis comparing AMD and normal eye tissues to identify gene signatures associated with the disease.
- The study found over 50 genes related to immune responses that are over-expressed in AMD, and identified key gene sets that help differentiate advanced AMD types, potentially aiding in clinical diagnosis and understanding of disease progression.
We introduce a human retinal pigmented epithelial (RPE) cell-culture model that mimics several key aspects of early stage age-related macular degeneration (AMD). These include accumulation of sub-RPE deposits that contain molecular constituents of human drusen, and activation of complement leading to formation of deposit-associated terminal complement complexes. Abundant sub-RPE deposits that are rich in apolipoprotein E (APOE), a prominent drusen constituent, are formed by RPE cells grown on porous supports.
View Article and Find Full Text PDFObjective: To estimate the minimally important difference (MID) for a fatigue visual analog scale (VAS) using patient-reported anchors (fatigue, pain, and overall health).
Methods: Patients with rheumatoid arthritis (RA; n = 307) had 2 clinic visits at a median of 5.9 months apart.
Ovotestis (intersex) and raised plasma vitellogenin in male fish are widely employed biomarkers of estrogen contamination in the aquatic environment. In the present study, these biomarkers were used to determine whether Irish rivers contain estrogenic chemicals at levels capable of affecting the reproductive health and success of exposed fish populations. A number of aquatic ecosystems were investigated (the rivers Liffey, Lee, and Bandon and the Killarney lakes).
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