Young obese women with polycystic ovary syndrome have evidence of early coronary atherosclerosis.

Context: Polycystic ovary syndrome (PCOS) is associated with comorbidities that may contribute to increased risk of cardiovascular disease. PCOS is associated with increased risk of metabolic syndrome, dyslipidemia, and diabetes, but it remains unclear whether traditional cardiovascular (CV) risk factors can help predict coronary artery disease in this population.

Objective: The objectives of the study were to detect early-onset subclinical coronary atherosclerosis (using coronary artery calcium as a marker) in young women with PCOS, compared with age- and body mass index-matched controls, and to compare traditional CV risk factors and inflammatory markers in the two groups.

Increased risk of depressive disorders in women with polycystic ovary syndrome.

Objective: Polycystic ovary syndrome (PCOS) is associated with several metabolic complications. A few small studies have also suggested an increased risk of depression in women with PCOS. The goals of this study were to estimate the prevalence of depressive disorders in women with PCOS compared with controls and to evaluate the correlation between depression, hyperandrogenism, and other metabolic markers.

Obesity and insulin resistance but not hyperandrogenism mediates vascular dysfunction in women with polycystic ovary syndrome.

Objective: Polycystic ovary syndrome (PCOS) is associated with biochemical evidence of early atherosclerosis; however, data regarding vascular function are controversial. We hypothesized that resistance vessel function (mediated by the endothelium or smooth muscle) would be impaired in women with PCOS and aimed to determine the contribution of hyperandrogenism, obesity, or insulin resistance to vascular dysfunction.

Design: Prospective study.

A prospective randomized trial comparing anastrozole and clomiphene citrate in an ovulation induction protocol using gonadotropins.

Objective: To compare the ovarian and endometrial effects of anastrozole and clomiphene when used with gonadotropins in a combination protocol.

Design: Prospective randomized trial.

Setting: Academic infertility center.

Decision making regarding multifetal reduction.

Objective: To identify salient variables that influence decision making regarding multifetal reduction (MFR) and describe their effect on individuals over time.

Design: Prospective, exploratory, descriptive design, using qualitative and quantitative methods.

Setting: Midwestern tertiary care center.