Secondary peristalsis and esophagogastric junction distensibility in symptomatic post-fundoplication patients.

Background: The impact of esophageal dysmotility among patients with post-fundoplication esophageal symptoms is not fully understood. This study aimed to investigate secondary peristalsis and esophagogastric junction (EGJ) opening biomechanics using functional lumen imaging probe (FLIP) panometry in symptomatic post-fundoplication patients.

Methods: Eighty-seven adult patients post-fundoplication who completed FLIP for symptomatic esophageal evaluation were included.

Targeting PEA3 transcription factors to mitigate small cell lung cancer progression.

Small cell lung cancer (SCLC) remains a lethal disease with a dismal overall survival rate of 6% despite promising responses to upfront combination chemotherapy. The key drivers of such rapid mortality include early metastatic dissemination in the natural course of the disease and the near guaranteed emergence of chemoresistant disease. Here, we found that we could model the regression and relapse seen in clinical SCLC in vitro.

Acute Respiratory Distress Syndrome: An Unexpected Outcome of Suspected Viral Gastroenteritis.

Acute respiratory distress syndrome (ARDS) is a life-threatening manifestation of diffuse inflammation damaging the lung pleura. Risk factors for development are numerous with most cases arising in those already hospitalized for critical illness. We describe a unique case of a healthy 20-year-old female developing myocarditis and severe ARDS while hospitalized for septic shock after initially presenting with gastroenteritis from a suspected Coxsackie B infection in the setting of an overseas military deployment.

Comparison of a Novel Trainer to a Traditional Swine Model for Training Providers in Lateral Canthotomy and Cantholysis.

Research Objective: Military personnel are at greater risks of head and facial traumas and permanent blindness from orbital compartment syndrome in modern warfare. Rapid treatment must be implemented with a low-risk surgical remedy: lateral canthotomy and cantholysis (LCC). Traditional training of LCC is primarily performed using an animal tissue trainer (ATT); however, limitations to these types of trainers exist.