Publications by authors named "Michelle M Hanna"
Article Synopsis
- Neuroendocrine prostate cancer (NEPC) is a deadly type of prostate cancer that can arise naturally or from ordinary prostate adenocarcinoma after hormone treatments.
- The long noncoding RNA (lncRNA) H19 plays a crucial role in NEPC by influencing cell identity and treatment resistance, with higher levels of H19 linked to more aggressive disease characteristics.
- H19 is proposed as both a diagnostic and predictive marker for NEPC, with its levels indicating the likelihood of cancer recurrence and metastasis in patients undergoing androgen deprivation therapy.
Aim: Development of a sensitive method for DNA methylation profiling and associated mutation detection in clinical samples.
Materials & Methods: Formalin-fixed and paraffin-embedded tumors received by clinical laboratories often contain insufficient DNA for analysis with bisulfite or methylation sensitive restriction enzymes-based methods. To increase sensitivity, methyl-CpG DNA capture and Coupled Abscription PCR Signaling detection were combined in a new assay, MethylMeter(®).