Publications by authors named "Michelle Lorraine Frost"
Purpose: We describe a semipopulation input function for evaluating bone plasma clearance from static and dynamic (18)F-fluoride PET scans.
Methods: The semipopulation input function was derived by fitting an exponential curve to venous plasma measurements obtained 30-60 min after injection and adding a population residual curve representing the bolus peak scaled for injected activity and adjusted for time of peak counts. The residual curve was found from nine postmenopausal women who had continuous arterial blood samples and venous samples taken every 10 min.