Mediterranean diet and 3-year Alzheimer brain biomarker changes in middle-aged adults.

Objective: To examine in a 3-year brain imaging study the effects of higher vs lower adherence to a Mediterranean-style diet (MeDi) on Alzheimer disease (AD) biomarker changes (brain β-amyloid load via C-Pittsburgh compound B [PiB] PET and neurodegeneration via F-fluorodeoxyglucose [FDG] PET and structural MRI) in midlife.

Methods: Seventy 30- to 60-year-old cognitively normal participants with clinical, neuropsychological, and dietary examinations and imaging biomarkers at least 2 years apart were examined. These included 34 participants with higher (MeDi+) and 36 with lower (MeDi-) MeDi adherence.