Publications by authors named "Michelle Lippmann"
Article Synopsis
- PARP1 is a key sensor for cellular damage, specifically DNA strand breaks, which helps in DNA repair by recruiting XRCC1 and forming repair complexes.
- The study shows that the recruitment of PARP1 and XRCC1 to DNA damage sites is mutually dependent, emphasizing their collaboration in responding to genotoxic stress.
- Experiments using various cell types revealed that XRCC1 KO cells are more sensitive to certain DNA-damaging treatments, and this sensitivity can be mitigated by further genetic modifications or pharmacological interventions targeting PARP1.
Poly(ADP-ribosyl)ation regulates numerous cellular processes like genome maintenance and cell death, thus providing protective functions but also contributing to several pathological conditions. Poly(ADP-ribose) (PAR) molecules exhibit a remarkable heterogeneity in chain lengths and branching frequencies, but the biological significance of this is basically unknown. To unravel structure-specific functions of PAR, we used PARP1 mutants producing PAR of different qualities, i.
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