Statin Decreases Burden in Macrophages by Promoting Autophagy.

Statins, 3-hydroxy-3-methyl-glutaryl-coenzyme A (HMG-CoA) reductase inhibitors, have been found to provide protective effects against several bacterial infectious diseases. Although the use of statins has been shown to enhance antimicrobial treated eradication and reduce -mediated inflammation, the mechanisms underlying these effects remain unclear. In this study, and macrophage models were established to investigate the molecular pathways involved in statin-mediated inhibition of .