Publications by authors named "Michelle L Shui"
ACS Med Chem Lett
November 2024
Article Synopsis
- Antimicrobial peptides (AMPs) are promising against bacterial infections, and hybrid peptides, formed by linking two AMPs, may enhance their effectiveness.
- The study investigates hybrid peptides made from two histone-derived AMPs, BF2 and DesHDAP1, which show increased antimicrobial properties while remaining non-toxic to eukaryotic cells.
- The enhanced activity is due to a change in mechanism, where hybrid peptides have lower translocation across bacterial membranes but greater membrane permeabilization than the individual parent peptides.
