Publications by authors named "Michelle L McKenna"
Neurooncol Adv
August 2020
Article Synopsis
- - Oligodendroglioma diagnosis relies on detecting IDH mutations and 1p/19q codeletion, but traditional FISH testing can inaccurately show partial codeletions as positive, leading to false-positive results.
- - Researchers used chromosomal microarray data to assess the frequency of false positives in FISH codeletion tests and found a 3.6% misdiagnosis rate.
- - The study recommends careful testing and interpretation of 1p/19q codeletion results, especially when there are inconsistencies between FISH and histopathological findings, to minimize misdiagnosis risks.
