Publications by authors named "Michelle L Grigat"
Thermostable cross-protective subunit vaccine against Brucella species.
Clin Vaccine Immunol
December 2014
Article Synopsis
- A subunit vaccine was developed from Brucella suis 145, targeting Brucella abortus and Brucella melitensis, primarily consisting of polysaccharides and a small amount of protein, but no nucleic acids.
- Mice vaccinated with this candidate showed significant protection against Brucella species, with doses as low as 1 ng being effective and lasting immunological responses observed for up to 14 months.
- The vaccine was heat-stable and safe to produce, demonstrating strong immunogenicity and protection, making it a promising candidate for further studies in combating Brucella infections.