Discrepant Hemophilia A: An Underdiagnosed Disease Entity.

Objectives: The term discrepant hemophilia A (DHA) denotes the discrepancy between factor VIII activity (FVIII:C) measured by different assay methodologies in patients with nonsevere hemophilia A (HA). The objective was to review the characteristics and the current understanding of mechanisms contributing to assay discrepancy in DHA.

Methods: Characteristics of the DHA patients treated were examined by retrospective chart review.