King Rail () presence in the Midwestern United States is predicted by local-scale factors and avian community.

The King Rail () is a wetland dependent species of conservation concern. Our objective was to gain a better understanding of the breeding habitat associations of King Rails in the Midwestern United States and the relationship of this species to other obligate marsh birds using occupancy and MaxEnt models. To collect data pertaining to occupancy, we placed trail cameras at 50 random points in coastal wetlands in the western Lake Erie basin where calls of King Rails were continuously broadcast at night.

Use of a specialty clinic to teach a standardized approach to mood disorders in a family medicine residency.

The Mood Disorder Clinic was started at the Cone Family Medicine Residency in 2004 with the threefold purpose of providing a patient care service to a largely uninsured or underinsured population; teaching Family Medicine resident physicians how to more accurately identify, diagnose, and treat mood disorders in their patients; and modeling a team-based approach to addressing mental stress, distress, and dysfunction in the primary care setting. The authors present the logistics of the clinic and the standard approach to mood issues that is taught to resident physicians. Formal feedback suggests that the resident physicians find the experience useful in developing psychiatric knowledge and skills.

Improving alcohol withdrawal outcomes in acute care.

Context: Excessive alcohol consumption is the nation's third leading cause of preventable deaths. If untreated, 6% of alcohol-dependent patients experience alcohol withdrawal, with up to 10% of those experiencing delirium tremens (DT), when they stop drinking. Without routine screening, patients often experience DT without warning.

Identification of an N-terminal glycogen synthase kinase 3 phosphorylation site which regulates the functional localization of polycystin-2 in vivo and in vitro.

PKD2 is mutated in 15% of patients with autosomal dominant polycystic kidney disease. Polycystin-2 (PC2), the PKD2 protein, is a non-selective Ca(2+)-permeable cation channel which may function at the cell surface and ER. Nevertheless, the factors that regulate the dynamic translocation of PC2 between the ER and other compartments are not well understood.

Polycystin-1, STAT6, and P100 function in a pathway that transduces ciliary mechanosensation and is activated in polycystic kidney disease.

Primary cilia are implicated in the pathogenesis of autosomal-dominant polycystic kidney disease (ADPKD), which results from defects in polycystin-1 (PC1), but the function of PC1 remains poorly understood. Here, we show that PC1 undergoes proteolytic cleavage that results in nuclear translocation of its cytoplasmic tail. The PC1 tail interacts with the transcription factor STAT6 and the coactivator P100, and it stimulates STAT6-dependent gene expression.