Publications by authors named "Michelle K Leonard"
Hypoxia-specific imaging in patients with lymphoma undergoing CAR-T therapy.
Eur J Nucl Med Mol Imaging
September 2023
Article Synopsis
- The study investigated the impact of intratumoral hypoxia on chimeric antigen receptor T-cell (CAR-T) therapy in non-Hodgkin's Lymphoma (NHL) using a PET imaging technique called [F]FAZA.
- Of the 16 patients scanned, a minimal number showed significant hypoxia, with only one patient meeting the threshold for intratumoral hypoxia and experiencing early treatment failure.
- Due to the low incidence of positive scans indicating hypoxia, the study was halted for being unlikely to yield meaningful results, and future research may focus on a more selective patient group.