Publications by authors named "Michelle Jojy"
Di-2-ethylhexyl terephthalate (DEHTP) is a replacement for its structural isomer di-2-ethylhexyl phthalate (DEHP), a known endocrine disrupting chemical and ovarian toxicant. DEHTP is used as a plasticizer in polyvinyl chloride products and its metabolites are increasingly found in biomonitoring studies at levels similar to phthalates. However, little is known about the effects of DEHTP on the ovary.
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- Di-2-ethylhexyl terephthalate (DEHTP) is being studied as a substitute for the harmful chemical DEHP, linked to reproductive issues, particularly in the ovaries, but its effects are not yet well understood.
- The research involved exposing young adult mice to different doses of DEHTP and its metabolite, MEHTP, and assessing impacts on ovarian follicle counts, hormone levels, and gene expression related to cell regulation and apoptosis.
- Findings revealed that DEHTP impacted follicle counts and reduced hormonal balances, suggesting both DEHTP and MEHTP might be toxic to the ovaries and warrant further investigation due to their structural similarities to phthalates.