Comparison of Hyperpolarized He and Xe MR Imaging in Cystic Fibrosis Patients.

Purpose: In this study, we compared hyperpolarized He and Xe images from patients with cystic fibrosis using two commonly applied magnetic resonance sequences, standard gradient echo (GRE) and balanced steady-state free precession (TrueFISP) to quantify regional similarities and differences in signal distribution and defect analysis.

Materials And Methods: Ten patients (7M/3F) with cystic fibrosis underwent hyperpolarized gas MR imaging with both He and Xe. Six had MRI with both GRE, and TrueFISP sequences and four patients had only GRE sequence but not TrueFISP.