Comparison of the Protective Effect of and Infusions Against Hepatic Damage Induced by Hypotermic-Ischemia in Rats.

We aimed to evaluate, in this study, the effect of L. and L. in the amelioration of liver hypothermic conservation in male wistar rats.

Grape seed and skin extract protects against bleomycin-induced oxidative stress in rat lung.

Introduction: Lung fibrosis is a common side effect of the chemotherapeutic agent bleomycin and current evidence suggests that reactive oxygen species play a key role in the development of lung injury. We examined whether grape seed and skin extract (GSSE), a polyphenolic mixture exhibiting antioxidant properties, is able to protect against bleomycin-induced lung oxidative stress and injury.

Methods: Rats were pre-treated during three weeks either with vehicle (ethanol 10% control) or GSSE (4g/kg), then administered with a single high dose bleomycin (15mg/kg) at the 7th day.

Resveratrol, a red wine polyphenol, attenuates ethanol-induced oxidative stress in rat liver.

The involvement of oxidative stress in the pathogenesis of alcoholic diseases in the liver has been repeatedly confirmed. Resveratrol, a natural phytoalexin present in grape skin and red wine possesses a variety of biological activities including antioxidant. This study was conducted to evaluate whether resveratrol has a preventive effect on the main indicators of hepatic oxidative status as an expression of the cellular damage caused by free radicals, and on antioxidant defence mechanism during chronic ethanol treatment.