Publications by authors named "Michelle E Keyel"
Article Synopsis
- * A new liquid chromatography-mass spectrometry (LC-MS) method was developed to effectively profile gangliosides, optimizing both the extraction and analysis processes for better accuracy and recovery.
- * This study found that the ganglioside profiles vary significantly across different cancer cell lines, indicating the potential of the method for identifying specific lipid markers related to cancer types.
GD2, a disialoganglioside, is present on the surface of most neuroblastomas, as well as on some other cancers, such as melanoma and osteogenic sarcoma. The anti-GD2 antibody ch14.18 (dinutuximab) has an FDA-registered indication for use as maintenance therapy for high-risk neuroblastoma with cytokines and 13-cis-retinoic acid after myeloablative therapy.
View Article and Find Full Text PDFNeuroblastoma (NB) is a pediatric cancer of the sympathetic nervous system which accounts for 8% of childhood cancers. Most NBs express high levels of the disialoganglioside GD2. Several antibodies have been developed to target GD2 on NB, including the human/mouse chimeric antibody ch14.
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