Publications by authors named "Michelle Dubuc-Mageau"
Article Synopsis
- The corrected QT (QTc) interval is a key biomarker for proarrhythmic risk, but its use has limitations that are explored in this study, alongside the alternative biomarker J to T-peak (JTp).
- The study involved Beagle dogs under different body temperature conditions and epinephrine administration to assess effects on QT, JTp, and T-peak intervals using various medications.
- Findings revealed that body temperature significantly affects QT and JTp intervals, while T-peak was less influenced; pharmacological agents had specific impacts on these intervals, highlighting potential confounding factors in ECG interpretation during drug safety testing.
Minipigs are an emerging nonrodent alternative for ocular toxicology owing to anatomical similarities in the minipig eyes when compared to humans. Ocular structures and components from Göttingen minipigs were characterized and compared to species commonly used in toxicology. Ocular reference data from Göttingen minipig including intraocular pressure, vitreous electrolyte and thiol concentration, and electroretinography (ERG) data are essential to model characterization and data interpretation during drug safety assessments.
View Article and Find Full Text PDFReprint of "EEG: Characteristics of drug-induced seizures in rats, dogs and non-human primates".
J Pharmacol Toxicol Methods
July 2019
Seizures are amongst the most frequent neurological issues encountered in pre-clinical safety testing. The objective was to characterize EEG morphologies and premonitory signs in drug-induced seizures in preclinical species. A comparative (inter-species) retrospective analysis for drug-induced seizures recorded by video-telemetry was conducted in rats (n = 53), dogs (n = 195), and non-human primates (n = 234).
View Article and Find Full Text PDFEEG: Characteristics of drug-induced seizures in rats, dogs and non-human primates.
J Pharmacol Toxicol Methods
November 2019
Seizures are amongst the most frequent neurological issues encountered in pre-clinical safety testing. The objective was to characterize EEG morphologies and premonitory signs in drug-induced seizures in preclinical species. A comparative (inter-species) retrospective analysis for drug-induced seizures recorded by video-telemetry was conducted in rats (n = 53), dogs (n = 195), and non-human primates (n = 234).
View Article and Find Full Text PDF