Publications by authors named "Michelle Botelho Caarls"
Tissue engineering demands the development of scaffolds that mimic natural extracellular matrices (ECM). Despite the success in obtaining synthetic interstitial ECM, the production of an artificial basement membrane (BM), the specialized thin sheet of ECM that is pivotal for the functional organization of most tissues and internal organs, is still not achieved. With the long-term aim of developing a flat BM-like structure here we investigated the behavior of acid-soluble Col IV during simultaneous assembly with laminin (LM) in acidic conditions.
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- - The Hexosamine Biosynthetic Pathway (HBP) produces UDP-GlcNAc, a crucial substrate for protein glycosylation, and plays a role in altered glucose metabolism and glycosylation in cancer cells, particularly in melanoma.
- - This study shows that increased HBP activity and GlcNAcylation reduce the motility and migration of melanoma cells, which are key processes in the development of metastasis.
- - Additionally, inhibiting specific types of glycosylation reduces cell migration, and high HBP activity lowers the activity of metalloproteases, indicating that both HBP modulation and glycosylation affect cell movement.
A 24-year-old Caucasian female patient was referred to our endocrinology service to investigate a structural magnetic resonance imaging (sMRI) finding of "pituitary mass". The first two sMRI were identified as pituitary adenoma but the following two examinations suggested the possibility of pituitary hyperplasia (PH). The patient was referred to our service for diagnostic clarification and therapy due to the divergence in sMRI reports and the surgical procedure indicated by the neurosurgical team of the other institution.
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