Point-of-Care Ultrasound in Resource-Limited Settings.

Point-of-care ultrasound (POCUS) bridges diagnostic gaps across the continuum of care worldwide and is a particularly potent tool in resource-limited settings (RLS). To capture the scope of its current impact in RLS, this narrative review of POCUS use in public health, primary care, outpatient specialty, pre-hospital, and palliative care settings discusses its use in reducing diagnostic health care inequities. Disease-specific protocols, longitudinal training, quality assurance, and task shifting are key to robust expansion of POCUS in RLS.

To Know the Disease: Creating a Participatory Community Education Workshop about Focused on Physical, Economic, and Epidemiologic Evidence.

Cysticercosis, caused by , is a neglected disease that causes preventable epilepsy. We conducted an experiential learning workshop in northern Peru to educate community members on transmission and motivate participation in community-led prevention and control. The workshop included presentation of local economic and epidemiologic data, followed by hands-on participation in pig dissection, group discussion of the life cycle, and viewing of eggs and nascent tapeworms with light microscopes.

Evaluating Urban Taeniasis as a Threat to Cysticercosis Elimination in Northern Peru.

Reintroduction of into a region in Peru where it had been eliminated prompted evaluation of the possibility of reintroduction from an urban reservoir of taeniasis. In a cross-sectional study of an adjacent urban area, we found low prevalence of taeniasis (4/1,621; 0.25%), suggesting minimal risk of parasite reintroduction into rural areas through this route.

Barriers to Participation in a Community-Based Program to Control Transmission of in Peru.

Infection of the brain with larvae (neurocysticercosis) is a leading cause of preventable epilepsy worldwide. Effective and sustainable strategies to control parasite transmission in rural endemic communities are needed to prevent the disease. Surveillance and targeted intervention around infected pigs (ring control strategy) have been shown to be effective when carried out by research teams.

Sirtuins regulate proteomic responses near thermal tolerance limits in the blue mussels and .

The blue mussels and are competing species with biogeographical ranges set in part by environmental exposure to heat and hyposalinity. The underlying cellular mechanisms influencing interspecific differences in stress tolerance are unknown, but are believed to be under regulation by sirtuins, nicotinamide adenine dinucleotide (NAD)-dependent deacylases that play a critical role in the cellular stress response. A comparison of the proteomic responses of and to an acute heat shock in the presence and absence of the sirtuin inhibitor suramin (SIRT1, 2 and 5) showed that sirtuins affected molecular chaperones, oxidative stress proteins, metabolic enzymes, cytoskeletal and signaling proteins more in the heat-sensitive than in the heat-tolerant Interactions between sirtuin inhibition and changes in the abundance of proteins of β-oxidation and oxidative stress in suggest a greater role of sirtuins in shifting metabolism to reduce the production of reactive oxygen species near thermal limits.

Failure of lung isolation by a double-lumen endotracheal tube rescued by the concomitant use of an arndt bronchial blocker under direct visualization.

Failure of a double-lumen endotracheal tube (DLT) to isolate the lung during thoracic surgery can have significant consequences. In this report, we examine an approach for rescuing a malpositioned DLT. A 37F left-sided DLT was inserted and its proper position confirmed.