MRI and Ultrasound Visualization of a Nerve Repair Implant Containing Nitinol.

Background: Nerve Tape is a novel nerve repair device containing nitinol microhooks that provide sutureless attachment for nerve coaptation. This study evaluated visualization of Nerve Tape on magnetic resonance imaging (MRI) and ultrasound, with the objective of exploring its potential as an imaging marker for localizing nerve repair sites.

Methods: Phantom imaging experiments were first conducted to assess the visibility of Nerve Tape on MRI and ultrasound.

Extracting decision-making features from the unstructured eye movements of clinicians on glaucoma OCT reports and developing AI models to classify expertise.

This study aimed to investigate the eye movement patterns of ophthalmologists with varying expertise levels during the assessment of optical coherence tomography (OCT) reports for glaucoma detection. Objectives included evaluating eye gaze metrics and patterns as a function of ophthalmic education, deriving novel features from eye-tracking, and developing binary classification models for disease detection and expertise differentiation. Thirteen ophthalmology residents, fellows, and clinicians specializing in glaucoma participated in the study.

Inverse Volcano: A New Molecule-Surface Interaction Phenomenon.

Explosive desorption of guest molecules embedded in amorphous solid water upon its crystallization is known as the "molecular volcano." Here, we describe an abrupt ejection of NH_{3} guest molecules from various molecular host films toward a Ru(0001) substrate upon heating, utilizing both temperature programmed contact potential difference and temperature programmed desorption measurements. NH_{3} molecules abruptly migrate toward the substrate due to either crystallization or desorption of the host molecules, following an "inverse volcano" process considered a highly probable phenomenon for dipolar guest molecules that strongly interact with the substrate.

Chemical Reactivity of Strongly Interacting, Hydrogen-Bond-Forming Molecules Following 193 nm Photon Irradiation: Methanol in Amorphous Solid Water at Low Temperatures.

Mixtures of methanol and amorphous solid water (ASW) ices are observed in the interstellar medium (ISM), where they are subject to irradiation by UV photons and bombardment by charged particles. The charged particles, if at high enough density, induce a local electric field in the ice film that potentially affects the photochemistry of these ices. When CDOD@ASW ices grown at 38 K on a Ru(0001) substrate are irradiated by 193 nm (6.

Distribution of Weakly Interacting Atoms and Molecules in Low-Temperature Amorphous Solid Water.

Understanding the distribution and mixing of atoms and molecules in amorphous solid water (ASW) at low temperatures is relevant to the exploration of the astrochemical environment in the interstellar medium (ISM) that leads to the formation of new complex molecules. In this study, a combination of temperature programmed desorption (ΔP-TPD) experiments and Ne ion sputtering is used to determine the extent of mixing and distribution of guest atoms and molecules within thin ASW films deposited at 35 K on a Ru(0001) substrate, prior to sputtering. The mixing of krypton atoms and methyl chloride molecules within thin ASW films is directed by the physical properties of the respective species and the nature of their interaction with the host water molecules.

Same-Energy UV Photons and Low-Energy Electrons Activating Methane and Ammonia Frozen in Amorphous Solid Water.

UV photons and low-energy electrons play an important role in the evolution of various molecules in the interstellar medium (ISM). Here, we examined the product molecule formation as a result of irradiation of 193 nm photons and 6.4 eV electrons (same energy under identical laboratory conditions) on DO|CH + ND|DO sandwiched films deposited on Ru(0001) substrate at 25 K in ultrahigh vacuum as a model for processes in the ISM.

The role of thermal history on spontaneous polarization and phase transitions of amorphous solid water films studied by contact potential difference measurements.

Monitoring thermal processes occurring in molecular films on surfaces can provide insights into physical events such as morphology changes and phase transitions. Here, we demonstrate that temperature-programmed contact potential difference (TP-∆CPD) measurements employed by a Kelvin probe under ultrahigh vacuum conditions and their temperature derivative can track films' restructure and crystallization occurring in amorphous solid water (ASW) at temperatures well below the onset of film desorption. The effects of growth temperature and films' thickness on the spontaneous polarization that develops within ASW films grown at 33 K-120 K on top of a Ru(0001) substrate are reported.

Spontaneous polarization of thick solid ammonia films.

Ammonia molecules have an important role in the radiation-induced chemistry that occurs on grains in the cold interstellar medium and leads to the formation of nitrogen containing molecules. Such grains and surfaces are primarily covered by water ices; however, these conditions allow the growth of solid ammonia films as well. Yet, solid ammonia know-how lags the vast volume of research that has been invested in the case of films of its "sibling" molecule water, which, in the porous amorphous phase, spontaneously form polar films and can cage coadsorbed molecules within their hydrogen-bonded matrix.

AMG 837: a potent, orally bioavailable GPR40 agonist.

The discovery that certain long chain fatty acids potentiate glucose stimulated insulin secretion through the previously orphan receptor GPR40 sparked interest in GPR40 agonists as potential antidiabetic agents. Optimization of a series of β-substituted phenylpropanoic acids led to the identification of (S)-3-(4-((4'-(trifluoromethyl)biphenyl-3-yl)methoxy)phenyl)hex-4-ynoic acid (AMG 837) as a potent GPR40 agonist with a superior pharmacokinetic profile and robust glucose-dependent stimulation of insulin secretion in rodents.

Optimization of 2-aminothiazole derivatives as CCR4 antagonists.

A series of 2-aminothiazole-derived antagonists of the CCR4 receptor has been synthesized and their affinity for the receptor evaluated using a [(125)I]TARC (CCL17) displacement assay. Optimization of these compounds for potency and pharmacokinetic properties led to the discovery of potent, orally bioavailable antagonists.