A case of cutaneous necrosis due to intra-articular hyaluronic acid and treated with hyaluronidase.

A 66-year-old woman presented to the hospital with cutaneous necrosis of her right ankle and foot. Her symptoms began immediately after an intra-articular injection of hyaluronic acid for ankle osteoarthritis, which was performed 6 days before. Histopathology showed an intra-vascular hyaluronic acid embolus.

Identification of genetic variants associated with skeletal muscle function deficit in childhood acute lymphoblastic leukemia survivors.

Although 80% of childhood acute lymphoblastic leukemia (ALL) cases are cured with current treatment protocols, exposure to chemotherapeutics or radiation therapy during a vulnerable period of child development has been associated with a high frequency of late adverse effects (LAE). Previous observations suggest important skeletal muscle size, density and function deficits in ALL survivors. Given that only a fraction of all patients will suffer from this particular complication, we investigated whether it could be predicted by genetic markers.

Identification of a single-nucleotide polymorphism within gene associated with bone morbidity in childhood acute lymphoblastic leukemia survivors.

To identify genetic markers associated with late treatment-related skeletal morbidity in survivors of childhood acute lymphoblastic leukemia (ALL). To this end, we measured the association between reduction in bone mineral density or vertebral fractures prevalence and variants from 1039 genes derived through whole exome sequencing in 242 childhood ALL survivors. Top-ranking variants were confirmed through genotyping, and further explored with stratified analyses and multivariable models.

Stability of laser-assisted in situ keratomileusis (LASIK) at altitude.

Background: The U.S. Air Force approved laser-assisted in situ keratomileusis (LASIK) for aircrew in May 2007.

Beyond 20/20: new clinical methods to quantify vision performance.

Objective: To describe the design, the sensitivity, and the application of new methods to quantify visual performance.

Methods: The super vision test-night vision goggle (SVT-NVG) is a new clinical letter chart that measures high- and low-contrast vision under daytime and simulated night conditions. The cone contrast test (CCT) is a computer-based color test that readily diagnoses type and severity of color deficiency.

Why preoperative acuity predicts postoperative acuity in wavefront-guided LASIK.

Purpose: To critically evaluate the following clinical wisdom regarding custom (wavefront-guided) laser in situ keratomileusis (LASIK) that subjects with better-than-average best-corrected visual acuity (BCVA) before surgery have a greater risk of losing BCVA postoperatively than do subjects with worse-than-average BCVA before surgery.

Methods: High contrast BCVA was measured once before and 3 months after custom LASIK in one eye of 79 subjects. Preoperative spherical equivalent refractive error ranged between -1.

The tubulin homologue FtsZ contributes to cell elongation by guiding cell wall precursor synthesis in Caulobacter crescentus.

The tubulin homologue FtsZ is well known for its essential function in bacterial cell division. Here, we show that in Caulobacter crescentus, FtsZ also plays a major role in cell elongation by spatially regulating the location of MurG, which produces the essential lipid II peptidoglycan cell wall precursor. The early assembly of FtsZ into a highly mobile ring-like structure during cell elongation is quickly followed by the recruitment of MurG and a major redirection of peptidoglycan precursor synthesis to the midcell region.

Mycobacteriophage Bxb1 integrates into the Mycobacterium smegmatis groEL1 gene.

Mycobacteriophage Bxb1 is a temperate phage of Mycobacterium smegmatis and forms stable lysogens in which the Bxb1 genome is integrated into the host chromosome. Bxb1 encodes an integrase of the large serine recombinase family that catalyses integration and excision of the Bxb1 genome. We show here that Bxb1 integrates into a chromosomal attB site located within the 3' end of the groEL1 gene such that integration results in alteration of the C-terminal 21 amino acid residues.