Publications by authors named "Michelle A Seaberg"
Arthritis Res Ther
January 2022
Article Synopsis
- The study focuses on the role of T cell activation in systemic sclerosis (SSc), a disease marked by fibrosis in skin and lungs, and evaluates the dual ICOS/CD28 antagonist, acazicolcept (ALPN-101), in mouse models resembling SSc.
- Acazicolcept was administered to two different SSc mouse models over six weeks, showing good tolerance and significant improvements in skin and lung fibrosis markers, including reduced dermal thickness and collagen content.
- The treatment also altered T cell populations in the spleen and lungs, indicating a potential therapeutic strategy for managing SSc by targeting immune activation.
