Intra-carotid hyperosmotic stimulation increases Fos staining in forebrain organum vasculosum laminae terminalis neurones that project to the hypothalamic paraventricular nucleus.

Body fluid hyperosmolality has long been known to elicit homeostatic responses that range from drinking to inhibition of salt appetite to release of neurohypohyseal hormones (i.e. vasopressin and oxytocin).

Identification of active central nervous system sites in renal wrap hypertensive rats.

To identify central neurons participating in cardiovascular regulation in hypertension, we studied Fos staining, a marker for synaptically activated neurons, in adult male normotensive and hypertensive (HT) rats. At 1 and 4 weeks after induction of unilateral nephrectomy, renal wrap hypertension mean arterial pressure was 138+/-4 mm Hg (n=6) in 1-week HT rats and 159+/-6 mm Hg (n=6) in 4-week HT rats. Mean arterial pressure was 103+/-2 mm Hg (n=6) in sham-operated, normotensive rats.