Publications by authors named "Michelle A Beutz"
This study aimed to identify receptors mediating sphingosine-1-phosphate (S1P)-induced vasoconstriction in the normotensive and chronic hypoxia-induced hypertensive rat pulmonary circulation. In isolated perfused lungs from normoxic rats, infusion of S1P caused a sustained vasoconstriction, which was not reduced by combinational pretreatment with the dual S1P(1 and 3) receptor antagonist VPC23019 and the S1P(2) receptor antagonist JTE013. The S1P(4) receptor agonists phytosphingosine-1-phospate and VPC23153, but not the dual S1P(1 and 3) receptor agonist VPC24191, caused dose-dependent vasoconstrictions.
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- Resident lung stem cells can replace various types of lung tissue, including mesenchyme, epithelium, and blood vessels.
- Current research is focused on understanding lung side population (SP) cells, which may serve as a source of adult stem cells specific to lung tissues.
- Adult mouse lung SP cells show potential for both epithelial and mesenchymal development, highlighting their role in tissue repair and the possibility of targeted treatments for lung injuries.
Sepsis is a frequent and often fatal complication of pneumonia. This article discusses the epidemiology, pathophysiology, and treatment of sepsis in the setting of pneumonia. Particular consideration is given to the role of mechanical ventilation in amplifying organ dysfunction in sepsis and to treatments that have positive effects on sepsis mortality and respiratory dysfunction.
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