Publications by authors named "Michelle‐Amirah Khalil"
Brain function requires a constant supply of glucose. However, the brain has no known energy stores, except for glycogen granules in astrocytes. In the present study, we report that continuous oligodendroglial lipid metabolism provides an energy reserve in white matter tracts.
View Article and Find Full Text PDFThe efficacy of antitumor immunity is associated with the metabolic state of cytotoxic T cells, which is sensitive to the tumor microenvironment. Whether ionic signals affect adaptive antitumor immune responses is unclear. In the present study, we show that there is an enrichment of sodium in solid tumors from patients with breast cancer.
View Article and Find Full Text PDFItaconate controls its own synthesis via feedback-inhibition of reverse TCA cycle activity at IDH2.
Biochim Biophys Acta Mol Basis Dis
December 2022
Article Synopsis
- Macrophages undergo significant metabolic changes during their M1-like pro-inflammatory polarization, particularly involving the production of itaconate, which plays roles in both facilitating and responding to inflammation.
- Itaconate is produced in macrophages through a specific mitochondrial process involving the enzyme aconitase decarboxylase 1 (ACOD1) and utilizes carbon sources from the TCA cycle.
- The study highlights that the balance between oxidative and reductive TCA cycle metabolism is crucial for itaconate synthesis, noting differences between mouse and human macrophages in how they respond to hypoxic conditions regarding itaconate production.