Publications by authors named "Michele-Corinne Ako"
A cross-sectional study of participant recruitment rates in published phase III influenza therapeutic randomized controlled trials conducted in the clinical setting.
Richard E Rothman Joshua D Niforatos Mehdi Youbi Nicholas Polydefkis Alaina Hergenroeder Michele-Corinne Ako
Am J Emerg Med
November 2022
Article Synopsis
- A cross-sectional study analyzed recruitment rates for influenza therapeutic Phase III RCTs from various clinical settings, including Emergency Departments (EDs), from 2000 to 2019.
- Out of 7,008 articles reviewed, only 47 were included, showing that most studies recruited from mixed clinical settings and only 5% exclusively from EDs.
- The results indicated that while studies reported high median enrollments overall, the recruitment rates were significantly higher in studies that focused exclusively on EDs compared to those recruiting from other settings.
Study Objective: In emergency departments (EDs), diagnosis and treatment of Chlamydia trachomatis and Neisseria gonorrhoeae are challenging. We conducted a randomized clinical trial to assess rapid C trachomatis and N gonorrhoeae testing on overtreatment and undertreatment of women evaluated for C trachomatis and N gonorrhoeae.
Methods: Women undergoing pelvic examinations and C trachomatis and N gonorrhoeae testing (n=254) were randomized to control or rapid test groups.