Evaluation of AMCase and CHIT-1 expression in monocyte macrophages lineage.

Acidic mammalian chitinase (AMCase) and chitotriosidase (CHIT-1) are two active chitinases expressed in humans. The chitinase activity of AMCase was found to be causative in allergic inflammation and its expression was found to be induced by interleukin-13. CHIT1-1 is expressed by phagocytic cells and extremely high levels are seen in lysosomal storage diseases.

Glucose ameliorates the metabolic profile and mitochondrial function of platelet concentrates during storage in autologous plasma.

Background: It is essential that the quality of platelet metabolism and function remains high during storage in order to ensure the clinical effectiveness of a platelet transfusion. New storage conditions and additives are constantly evaluated in order to achieve this. Using glucose as a substrate is controversial because of its potential connection with increased lactate production and decreased pH, both parameters triggering the platelet lesion during storage.

Evaluation of biochemical parameters in platelet concentrates stored in glucose solution.

Background: Therapeutic storage of platelet concentrate is a challenging problem for Transfusion Medicine, so that many studies have been carried out with the aim of improving the duration of storage of platelet concentrates. Little attention, however, has been given to the most appropriate biochemical methods for evaluating the quality of the stored platelet concentrates.

Material And Methods: [corrected] Platelet concentrates (n=10) were saved under gentle stirring at 22 masculineC for a total period of 8 days.