Sestamibi scintigraphy, topography, and histopathology of parathyroid glands in secondary hyperparathyroidism.

Background: Several imaging techniques presently are available to assess the location of hyperplastic parathyroid glands. The purpose of the present study is to assess the place of dual-phase technetium Tc 99m-sestamibi (MIBI) scintigraphy in the preoperative localization of hyperplastic parathyroid glands in patients with severe secondary hyperparathyroidism (SHPT).

Methods: We studied 35 consecutive adult white hemodialysis patients undergoing a first parathyroidectomy after performing MIBI scintigraphy.

Calcitriol pulse therapy and histology of parathyroid glands in hemodialysis patients.

Background: Calcitriol pulse therapy (CPT) is considered the most appropriate treatment of secondary hyperparathyroidism (sHPTH). This treatment inhibits parathyroid hormone (PTH) synthesis and secretion, suppresses parathyroid cell proliferation and controls parathyroid gland growth. However, not much is known about the effect of such therapy on parathyroid morphology.