Developing an Outcome Measure With High Luminance for Optogenetics Treatment of Severe Retinal Degenerations and for Gene Therapy of Cone Diseases.

Purpose: To present stimuli with varied sizes, colors, and patterns over a large range of luminance.

Methods: The filter bar used in scotopic MP1 was replaced with a custom slide-in tray that introduces light from an external projector driven by an additional computer. MP1 software was modified to provide retinal tracking information to the computer driving the projector.

Optimization of high-order harmonic generation by adaptive control of a sub-10-fs pulse wave front.

We present a method for the optimization of high-order harmonic generation based on wave-front correction of the driving laser beam. The technique exploits wave-front adaptive control by means of a deformable mirror, governed by an optimization procedure.