Publications by authors named "Michele Panepuccia"
Article Synopsis
- The study investigates the reasons behind the increased reactivity of T cells in newborns, focusing on specific molecular mechanisms that are not well understood.
- It identifies that neonatal naïve T cells produce more energy and proteins, linked to the lack of LINE1 expression due to specific signaling pathways.
- LINE1 expression increases with age, affecting T cell function and contributing to immune decline as people get older, suggesting its importance throughout human development.
The genome is no longer deemed as a fixed and inert item but rather as a moldable matter that is continuously evolving and adapting. Within this frame, Transposable Elements (TEs), ubiquitous, mobile, repetitive elements, are considered an alive portion of the genomes to date, whose functions, although long considered "dark", are now coming to light. Here we will review that, besides the detrimental effects that TE mobilization can induce, TEs have shaped genomes in their current form, promoting genome sizing, genomic rearrangements and shuffling of DNA sequences.
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