Publications by authors named "Michele Pablico-Lansigan"
There is an increasing need for gadolinium-free magnetic resonance imaging (MRI) contrast agents, particularly for patients suffering from chronic kidney disease. Using a cluster-nanocarrier combination, we have identified a novel approach to the design of biomedical nanomaterials and report here the criteria for the cluster and the nanocarrier and the advantages of this combination. We have investigated the relaxivity of the following manganese oxo clusters: the parent cluster Mn(OCCH)(Bpy) (1) where Bpy = 2,2'-bipyridine and three new analogs, Mn(OCCHCH═CH)(Bpy) (2), Mn(OCC(CH)═CH)(Bpy) (3), and MnO(OCCH)(Pyr) (4) where Pyr = pyridine.
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- The study focuses on the synthesis and properties of copper(I) halide coordination polymers created using various N-heteroaromatic ligands, which can bind to copper in either monodentate or bidentate forms.
- These polymers feature distinctive double-stranded "ladder" structures or single-stranded "zigzag" chains, depending on the ligand type and halide used.
- The luminescent properties of these compounds were analyzed, revealing emission peaks in the range of 550 to 680 nm and showcasing interesting features like delayed fluorescence and strong nonlinear optical responses, particularly noted in the compound [CuBr(quinazoline)].
Metal-oxo clusters have been used as building blocks to form hybrid nanomaterials and evaluated as potential MRI contrast agents. We have synthesized a biocompatible copolymer based on a water stable, nontoxic, mixed-metal-oxo cluster, Mn8Fe4O12(L)16(H2O)4, where L is acetate or vinyl benzoic acid, and styrene. The cluster alone was screened by NMR for relaxivity and was found to be a promising T2 contrast agent, with r1 = 2.
View Article and Find Full Text PDFMagnetic particle imaging (MPI) is an emerging biomedical imaging technology that allows the direct quantitative mapping of the spatial distribution of superparamagnetic iron oxide nanoparticles. MPI's increased sensitivity and short image acquisition times foster the creation of tomographic images with high temporal and spatial resolution. The contrast and sensitivity of MPI is envisioned to transcend those of other medical imaging modalities presently used, such as magnetic resonance imaging (MRI), X-ray scans, ultrasound, computed tomography (CT), positron emission tomography (PET) and single photon emission computed tomography (SPECT).
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