Clinical predictors of pathological gastro-oesophageal reflux in infants with persistent distress.

Background: Gastro-oesophageal reflux (GOR) is common in infants with persistent crying. Empirical treatment with antireflux medications is common practice, although on clinical grounds it may be difficult to determine whether GOR is abnormal.

Aims: To examine the diagnostic accuracy of clinical predictors of pathological GOR in infants with persistent crying.

Effect of antireflux medication, placebo and infant mental health intervention on persistent crying: a randomized clinical trial.

Objective: To assess the effect of medical antireflux treatment, and of an infant mental health consultation (IMHC), on persistent crying in infants and maternal distress.

Methods: Infants under 9 months of age with persistent crying, and their mothers, were enrolled in a randomized placebo-controlled trial. At enrollment, a questionnaire on demographic and clinical details was completed by mothers, and maternal distress was measured (Experience of Motherhood Questionnaire; EMQ).