Publications by authors named "Michele M Loi"
Outbreak of Invasive Group A Streptococcus in Children-Colorado, October 2022-April 2023.
J Pediatric Infect Dis Soc
October 2023
Background: In the fall of 2022, we observed a sharp rise in pediatric Invasive Group A Streptococcus (iGAS) hospitalizations in Colorado. We compared the epidemiology, clinical features, and patient outcomes in this outbreak to prior years.
Methods: Between October 2022 and April 2023, we prospectively identified and reviewed iGAS cases in hospitalized pediatric patients at Children's Hospital Colorado.
Article Synopsis
- The text discusses immune-related lung issues and inflammation in severe COVID-19 cases, especially focusing on how a small number of children can experience critical illness during their infection.
- A panel of pediatric specialists created guidelines for using immunomodulatory therapies for children with severe COVID-19 based on clinical severity and inflammation levels.
- The recommendations suggest that immunomodulatory therapy is usually not needed for mild cases, but could be beneficial for severe cases, highlighting the importance of evaluating each situation individually and preferring trial-based treatments when possible.
Accuracy of Bedside Ultrasound Femoral Vein Diameter Measurement by PICU Providers.
Pediatr Crit Care Med
December 2020
Objectives: Perform a needs assessment by evaluating accuracy of PICU provider bedside ultrasound measurement of femoral vein diameter prior to utilization of the catheter-to-vein ratio for central venous catheter size selection.
Design: Prospective observational cohort study.
Setting: PICU within a quaternary care children's hospital.
Background: Three methods of leukoreduction (LR) are used worldwide: filtration, buffy coat removal (BCR), and a combination of the previous two methods. Additionally, there are a number of additive solutions (ASs) used to preserve red blood cell (RBC) function throughout storage. During RBC storage, proinflammatory activity accumulates; thus, we hypothesize that both the method of LR and the AS affect the accumulation of proinflammatory activity.
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