The effects of advanced age on primary total knee arthroplasty: a meta-analysis and systematic review.

Background: Total knee arthroplasty is an effective treatment when nonsurgical treatments fail, but it is associated with risk of complications which may be increased in advanced age. The purpose of this study was to quantify age-related differences in perioperative morbidity and mortality after total knee arthroplasty through systematic review of existing literature.

Methods: PubMed, the Cochrane database of systematic reviews, Scopus, and clinicaltrials.