Publications by authors named "Michele M Elder"
Article Synopsis
- This study investigated how therapeutic apheresis affects chemokine gradients and leukocyte movement in a rat model of sepsis.
- The researchers found that apheresis significantly reduced plasma chemokines, which increased the recruitment of leukocytes to the infected peritoneal cavity while decreasing their presence in healthy tissues like the lung.
- Overall, the findings suggest that apheresis can enhance the body's immune response to infections by actively controlling the distribution of immune cells and reducing tissue damage.
Purpose: On-pump coronary artery bypass graft (CABG) surgery has been traditionally associated with a higher magnitude of inflammatory response than off-pump CABG. However with the development of polymer-coated biocompatible extracorporeal circuits, we wanted to see if cardiopulmonary bypass still played an important role in triggering this inflammatory response.
Methods: In this prospective observational study, 33 patients undergoing CABG surgeries (25 on-pump and 8 off-pump patients) were studied.