Publications by authors named "Michele L Scotti Buzhardt"
Article Synopsis
- PKCι is identified as an oncogene involved in lung and ovarian cancer, and is important for pancreatic cancer cell growth and maintenance.
- The study examines the effects of removing PKCι specifically in the pancreas, finding that this leads to increased immune cell infiltration, DNA damage, and cell death, while reducing the sensitivity to pancreatitis.
- Disrupting PKCι in pancreatic cells promotes early tumor formation but prevents further progression to a more aggressive cancer stage, highlighting its role in autophagy and cancer development.
Pancreatic cancer is highly resistant to current chemotherapies. Identification of the critical signaling pathways that mediate pancreatic cancer transformed growth is necessary for the development of more effective therapeutic treatments. Recently, we demonstrated that protein kinase C iota (PKCι) and zeta (PKCζ) promote pancreatic cancer transformed growth and invasion, by activating Rac1→ERK and STAT3 signaling pathways, respectively.
View Article and Find Full Text PDFPancreatic cancer is a very aggressive disease with few therapeutic options. In this study, we investigate the role of protein kinase C zeta (PKCζ) in pancreatic cancer cells. PKCζ has been shown to act as either a tumor suppressor or tumor promoter depending upon the cellular context.
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