Effect of concord grape juice on chemotherapy-induced nausea and vomiting: results of a pilot study.

Purpose/objectives: To determine the feasibility of administering a flavonoid-rich adjunctive treatment (Concord grape juice) for the management of chemotherapy-induced nausea and vomiting (CINV); to evaluate the usefulness of existing measures for assessing CINV frequency and severity, quality of life, control over life events, and psychological state; to identify any actual or potential adverse events associated with frequent grape juice intake; and to provide preliminary data concerning the effect of Concord grape juice on CINV, quality of life, perceived control over life events, and psychological state.

Design: Double-blind, randomized clinical trial.

Setting: A cancer center in an academic health science center in the northeastern United States.