Attenuation by a sigma1 (sigma1) receptor agonist of the learning and memory deficits induced by a prenatal restraint stress in juvenile rats.

1. Stress during pregnancy results in complex neurochemical and behavioral alterations throughout the offspring lifetime. We here examined the impact of prenatal stress (PS) on memory functions in male and female offspring and report the efficacy of a selective sigma(1) (sigma(1)) receptor agonist, igmesine, in alleviating the observed deficits.

Sex differences in learning deficits induced by prenatal stress in juvenile rats.

Stress during pregnancy results in neurochemical and behavioral alterations observed throughout adulthood and aging. We here examined the impact of prenatal stress (PS) on cognitive functions in juvenile-4-week-old-rats, focusing on putative sex differences. Dams received an unpredictable 90-min duration contention stress between gestational day E17 and E20.