Publications by authors named "Michele DI Toma"
Article Synopsis
- Multisystem Inflammatory Syndrome in Children (MIS-C) can occur 3-6 weeks after a SARS-CoV2 infection, and vaccinated adolescents show fewer severe cases, but data on younger kids is limited.
- A 6-year-old girl developed MIS-C symptoms one month after receiving her COVID-19 vaccine, despite having no prior detectable infection; diagnosis was confirmed through antibody tests.
- Treatment with immunoglobulins and steroids helped her recover, but she experienced additional complications like pancreatitis and neurological symptoms; follow-up showed no lasting issues, raising questions about the vaccine's role in MIS-C for younger children.
Background: The aim of the present study was to investigate outcomes of anti-TNF-alpha (ATA) withdrawal in selected pediatric patients with inflammatory bowel disease who achieved clinical remission and mucosal and histological healing (MH and HH).
Methods: A retrospective analysis was performed on children and adolescents affected by Crohn disease (CD) and ulcerative colitis (UC) who were followed up at 2 tertiary referral centers from 2008 through 2018. The main outcome measure was clinical relapse rates after ATA withdrawal.
Article Synopsis
- - The study assessed mucosal healing (MH) and histological healing (HH) outcomes in pediatric patients with inflammatory bowel disease (IBD) treated with anti-TNF-alpha agents at two centers.
- - Out of 170 patients, only 41% of those with Crohn's disease (CD) and 53.6% with ulcerative colitis (UC) achieved MH, while 33.3% of CD and 39.3% of UC patients achieved HH, indicating lower rates than previous studies.
- - Factors like achieving remission at the end of treatment were linked to higher MH and HH rates, while treatment with adalimumab showed lower rates of these healing outcomes, highlighting variability in patient responses
This study aimed to investigate the salivary microbiota and metabolome of 13 children with celiac disease (CD) under a gluten-free diet (treated celiac disease [T-CD]). The same number of healthy children (HC) was used as controls. The salivary microbiota was analyzed by an integrated approach using culture-dependent and -independent methods.
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